Natamycin, also known as pimaricin and sometimes sold as Natacyn, is a naturally occurring antifungal agent produced during fermentation by the bacterium Streptomyces natalensis, commonly found in soil. Natamycin is classified as a macrolide polyene antifungal, and as a drug, is used to treat fungal keratitis, an infection of the eye. Natamycin is also used in the food industry as a natural preservative. Natamycin is produced industrially by fermentation, using Streptomyces natalensis or Streptomyces gilvosporeus. Natamycin is extracted from the culture broth using butanol, after acidification to pH 3.0. The raw preparations then go through several purification stages, including precipitations, extractions and spray drying.
Global natamycin market was valued at 109.21 Million US$ in 2018 and is projected to reach 181.45 Million US$ by 2024, at a CAGR of 8.83% during the forecast period
Key players in global natamycin market include: Danisco, DSM, BASF, VGP Pharmachem, Beijing Oriental Rada Biotech, Zhejiang Silver Elephant Bioengineering, Lifecome Biochemistry, Meihua group, Handary, Siveele, Cayman Chemical, Shandong Freda Biotechnology, Pimaripro.